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How Do Allergies Work?

Published in Allergy Mechanisms 2 mins read

Allergies occur when the body's immune system overreacts to harmless substances called allergens. These reactions can range from mild to severe and significantly impact daily life.

Understanding the Allergic Reaction

The core of an allergy lies in the immune system's misidentification of a harmless substance as a threat. Here's a breakdown:

  • Allergens: These are substances that trigger allergic reactions. Common examples include pollen, pet dander, certain foods, and insect stings.
  • Immune System Overreaction: In people with allergies, the immune system mistakenly identifies these allergens as harmful invaders.
  • Antibody Production: The body produces specific antibodies called Immunoglobulin E (IgE) in response to the allergen.
  • Mast Cell Activation: These IgE antibodies attach to immune cells called mast cells, which are present throughout the body.
  • Chemical Release: When exposed to the same allergen again, the IgE antibodies on mast cells trigger the release of chemicals like histamine.
  • Allergic Symptoms: These chemicals cause the various symptoms associated with allergies, such as sneezing, itching, watery eyes, rashes, and in severe cases, anaphylaxis.

Types of Allergic Reactions

Allergic reactions can manifest in various ways:

Reaction Type Symptoms
Respiratory Sneezing, runny nose, coughing, wheezing, shortness of breath
Skin Itching, hives, rashes, eczema
Digestive Nausea, vomiting, diarrhea, stomach cramps
Systemic Anaphylaxis (severe reaction)

Common Allergens

  • Pollen: From trees, grasses, and weeds.
  • Food: Peanuts, tree nuts, milk, eggs, soy, wheat, fish, and shellfish.
  • Pet Dander: From cats, dogs, and other animals.
  • Insect Stings: Bee, wasp, and hornet stings.
  • Medications: Penicillin and other drugs.
  • Mold: Spores from mold found in damp areas.
  • Latex: Natural rubber found in some gloves and medical supplies.

Management and Treatment

  • Avoidance: The most effective way to manage allergies is to avoid exposure to known allergens.
  • Medications:
    • Antihistamines: Block the action of histamine, reducing symptoms.
    • Decongestants: Help to relieve nasal congestion.
    • Corticosteroids: Reduce inflammation.
    • Epinephrine Injectors (EpiPen): Used to treat anaphylaxis.
  • Allergy Shots (Immunotherapy): Gradually desensitizes the body to allergens.

According to provided information, allergies arise if the body's immune system overreacts to foreign substances (allergens) that are usually harmless in most people, such as pollen or certain foods.