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Can Allergy Medicine Cause Constipation?

Published in Allergy Medication Side Effects 2 mins read

Yes, certain types of allergy medicine can indeed cause constipation.

How Allergy Medications Can Lead to Constipation

Some medications, including specific types of allergy relief, can impact your digestive system's function. Based on the provided reference, medications used for conditions like allergies, such as diphenhydramine (Benadryl), and treatments for urinary incontinence, like oxybutynin (Ditropan), work by blocking the effects of a crucial chemical messenger in the body: acetylcholine.

The Role of Acetylcholine

Acetylcholine is essential for many bodily functions, including helping muscles contract. In your digestive tract, it plays a key role in the peristaltic movement – the wave-like muscle contractions that move food and waste through your gut.

Reduced Gut Movement

When medications like diphenhydramine (Benadryl) block the effects of acetylcholine, the muscles in your intestines become less active. This reduction in muscle movement means that waste moves through the digestive system more slowly. According to the reference, this less movement in the gut can lead to constipation.

Specific Examples

The reference specifically mentions diphenhydramine (Benadryl) as an allergy medication that can contribute to constipation due to its mechanism of blocking acetylcholine.

  • Diphenhydramine (Benadryl): A common over-the-counter antihistamine known for its sedating effects, it can also slow down gut motility.

If you are taking an allergy medicine and experiencing constipation, it's possible the medication is a contributing factor by affecting the function of acetylcholine and subsequently reducing gut movement.