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What is the Success Rate of Amivantamab?

Published in Amivantamab Success Rate 2 mins read

The success rate of amivantamab, specifically when used in combination with chemotherapy, is 73% for patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations. This rate reflects the percentage of patients who achieved an objective response, meaning either a complete or partial response to the treatment.

Understanding Amivantamab's Effectiveness

Amivantamab is an important therapeutic option, particularly for patients with NSCLC characterized by specific genetic mutations. The "success rate" in this context refers to the objective response rate (ORR), a standard measure in oncology clinical trials. It indicates the proportion of patients whose cancer significantly shrinks or disappears after treatment.

For patients with NSCLC involving EGFR exon 20 insertions, the combination of amivantamab and chemotherapy has demonstrated a notable efficacy profile compared to chemotherapy alone.

Key Findings on Objective Response Rates

The following table summarizes the objective response rates observed in clinical settings for patients with NSCLC and EGFR exon 20 insertion mutations:

Treatment Group Objective Response Rate 95% Confidence Interval
Amivantamab plus Chemotherapy 73% 65% to 80%
Chemotherapy Alone 47% 39% to 56%

As shown, the addition of amivantamab significantly improves the likelihood of achieving an objective response. The 73% success rate for the amivantamab–chemotherapy group highlights its potential to provide meaningful clinical benefit for these specific patients.

What is Amivantamab?

Amivantamab is a bispecific antibody approved for the treatment of advanced non-small cell lung cancer with EGFR exon 20 insertion mutations. It targets both epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition (MET) receptors, which are proteins that can drive cancer growth. Its mechanism involves blocking the activity of these receptors and recruiting immune cells to destroy cancer cells.

For more information on amivantamab and its approved uses, you can refer to resources from regulatory bodies like the U.S. Food and Drug Administration (FDA).