The largest foramen in the body is the obturator foramen.
This foramen is a large opening in the hip bone (pelvic bone). A foramen, by definition, is simply a natural opening or passage through a bone. The obturator foramen is located inferior to the acetabulum (the socket where the femur connects to the hip).
While other foramina exist in the body, such as the foramen magnum (in the skull), the obturator foramen is significantly larger. It's important to note that the obturator foramen isn't entirely "open" in a living person. The obturator membrane, a strong fibrous sheet, covers most of the opening, leaving only a small canal, the obturator canal, for the passage of the obturator nerve and vessels.
In summary, when discussing the size of foramina in the skeletal system, the obturator foramen stands out as the largest.