What Autoimmune Disease Affects the Bones?

Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoimmune disease that directly causes inflammation in the bones.

Understanding Chronic Recurrent Multifocal Osteomyelitis (CRMO)

CRMO, also known as chronic nonbacterial osteomyelitis (CNO), is a rare disorder characterized by inflammation within the bone. Unlike typical infections, this condition arises from the body's own immune system mistakenly attacking healthy bone tissue and organs.

In individuals with CRMO, the immune system, which is normally responsible for defending against foreign invaders like bacteria and viruses, erroneously targets the body's own cells. This misdirected attack leads to chronic inflammation, primarily affecting the bones. The resulting inflammation can cause pain and damage to the affected skeletal structures.

Key Characteristics of CRMO

CRMO presents with distinct features that set it apart as an autoimmune condition impacting the skeletal system.

• Rare Autoimmune Disorder: CRMO is considered uncommon, making diagnosis challenging due to its rarity.
• Bone Inflammation: The primary manifestation of the disease is persistent inflammation within the bones, which can occur in single or multiple locations.
• Immune System Misdirection: The condition's autoimmune nature means the body's defenses incorrectly identify healthy bone tissue as a threat.
• Alternative Naming: It is frequently referred to as Chronic Nonbacterial Osteomyelitis (CNO) to emphasize its non-infectious origin.

CRMO at a Glance