The full form of GBSA is Generalised Born and Surface Area solvation.
Understanding GBSA
GBSA is commonly used within the context of Molecular Mechanics with Generalised Born and Surface Area solvation (MM/GBSA). It is a method employed to calculate the free energy of binding of ligands to proteins. The reference specifies: "Molecular mechanics with generalised Born and surface area solvation (MM/GBSA) is a popular method to calculate the free energy of the binding of ligands to proteins."
In simpler terms, it helps scientists predict how strongly a molecule will attach to a protein, which is very important in drug discovery and understanding biological processes.
