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How many amino acids are in collagen?

Published in Biochemistry 1 min read

Collagen contains 19 amino acids.

Collagen, a crucial structural protein in the body, boasts a unique amino acid composition. While it comprises 19 different amino acids, it's particularly rich in glycine, proline, and hydroxyproline. This atypical composition distinguishes collagen from other proteins.

Key Features of Collagen's Amino Acid Profile:

  • High Glycine Content: Glycine constitutes approximately one-third of collagen's amino acid sequence. This small amino acid is essential for the tight triple-helix structure characteristic of collagen.

  • High Proline and Hydroxyproline Content: Proline and hydroxyproline contribute significantly to the stability of the collagen helix. Hydroxyproline is a modified amino acid unique to collagen and elastin.

  • Absence of Cysteine: Collagen lacks cysteine, an amino acid containing a sulfur atom. This absence is notable compared to many other proteins.

The specific amino acid sequence and modifications, such as the hydroxylation of proline, are critical for collagen's structural integrity and function. These features contribute to its ability to provide strength and support to tissues throughout the body.