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Is ceruloplasmin a protein?

Published in Biochemistry 1 min read

Yes, ceruloplasmin is indeed a protein. It is specifically an alpha-2 globulin protein synthesized in the liver. Its primary function is to store and transport copper in the bloodstream, carrying a significant portion (65-90%) of the copper found in blood.

In more detail:

  • Function: Ceruloplasmin plays a crucial role in copper metabolism. While it primarily functions as a copper transporter, it also exhibits ferroxidase activity, meaning it helps oxidize iron, which is important for iron homeostasis.

  • Synthesis: As mentioned earlier, ceruloplasmin is made in the liver. Conditions that impair liver function can lead to decreased ceruloplasmin levels.

  • Copper Binding: Each ceruloplasmin molecule can bind multiple copper atoms. This binding is essential for preventing copper toxicity and facilitating its delivery to various tissues.

  • Clinical Significance: Measuring ceruloplasmin levels is important in diagnosing certain medical conditions, such as Wilson's disease (a genetic disorder that prevents the body from properly removing copper) and copper deficiency. Low levels can also indicate malnutrition or malabsorption issues.