The full form of VEGF is Vascular Endothelial Growth Factor.
Vascular Endothelial Growth Factor (VEGF) is a crucial protein that plays a significant role in the formation of new blood vessels, a process known as angiogenesis. It was initially identified as a mitogen specific to endothelial cells, which line the interior of blood vessels.
Functions and Production of VEGF
- Angiogenesis: VEGF's primary function is to stimulate the growth of new blood vessels. This is vital for various physiological processes, such as wound healing and tissue development.
- Vascular Permeability: VEGF is also known as vascular permeability factor (VPF). It increases the permeability of blood vessels, which can be important in certain physiological and pathological conditions.
- Cell Production: Many cell types produce VEGF, including:
- Tumor cells
- Macrophages
- Platelets
- Keratinocytes
- Renal mesangial cells
The diverse range of cells that produce VEGF underscores its critical role in various biological functions. The reference provided states that VEGF is produced by tumor cells, macrophages, platelets, keratinocytes, and renal mesangial cells. This highlights the wide-ranging impact of VEGF in both healthy and diseased states.
