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What is HR+?

Published in Cancer Biology 2 mins read

HR+ refers to a type of tumor where the cancer cells possess receptors for the hormones estrogen or progesterone. This means that the presence of these hormones can promote the growth and proliferation of HR+ tumors.

Understanding Hormone Receptors (HR)

The term "HR" stands for Hormone Receptor. When a tumor is designated as HR+, it indicates a crucial characteristic: its cells are equipped with specific protein structures—receptors—that can bind to hormones like estrogen or progesterone.

Key characteristics of HR+ tumors:

  • Receptor Presence: HR+ tumors have receptors for either estrogen (Estrogen Receptor-positive, ER+) or progesterone (Progesterone Receptor-positive, PR+), or both.
  • Hormonal Dependence: The binding of these hormones to their respective receptors acts like a signal, stimulating the tumor cells to grow and divide. This hormonal dependency is a defining feature of HR+ cancers.

Why HR+ Status is Important

Understanding whether a tumor is HR+ is vital for guiding treatment strategies, particularly in hormone-sensitive cancers like breast cancer.

Practical Insights for HR+ Tumors:

  • Targeted Treatment: Because their growth is often fueled by hormones, HR+ tumors can frequently be treated with hormone therapy (also known as endocrine therapy). These treatments aim to:
    • Block the production of hormones (e.g., using aromatase inhibitors).
    • Block the hormone receptors on the cancer cells, preventing hormones from binding and stimulating growth (e.g., using drugs like tamoxifen).
  • Prognostic Information: HR+ status can also provide insights into the potential behavior of the tumor, often indicating a better response to hormone therapy and influencing long-term management plans.

Here's a quick overview of HR+ status:

Feature Description
HR Stands For Hormone Receptor
HR+ Meaning Tumor cells have receptors for the hormones estrogen or progesterone
Impact Hormones can promote the growth of these tumors
Treatment Link Often responsive to hormone therapy

It's worth noting that another important receptor in cancer classification is HER2. HER2 stands for human epidermal growth factor receptor 2. Like hormone receptors, HER2 status also guides specific targeted therapies, but for a different cellular pathway.