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Is Celiac an Allergy?

Published in Celiac Disease 2 mins read

No, celiac disease is not an allergy.

Celiac disease is often mistaken for a food allergy, but it's actually an autoimmune disorder. Unlike allergies, which trigger an immediate IgE-mediated immune response, celiac disease involves a different kind of immune reaction to gluten.

Here's a breakdown of the key differences:

  • Celiac Disease: An autoimmune disease triggered by gluten, a protein found in wheat, barley, and rye. In individuals with celiac disease, gluten consumption causes the immune system to attack the small intestine. This damages the villi, small finger-like projections that absorb nutrients, leading to malabsorption. Reactions are not typically immediate like an allergic reaction, and do not involve anaphylaxis.

  • Food Allergy: An immune response to a specific food protein. The body mistakenly identifies the protein as harmful and releases antibodies, leading to symptoms like hives, swelling, breathing difficulties, and potentially anaphylaxis (a severe, life-threatening allergic reaction).

Here's a table summarizing the differences:

Feature Celiac Disease Food Allergy
Type Autoimmune disease Allergic reaction
Trigger Gluten Specific food protein(s)
Immune Response Attack on the small intestine IgE-mediated reaction
Potential Outcome Damage to villi, malabsorption Hives, swelling, anaphylaxis
Anaphylaxis No Yes (in some cases)

While both celiac disease and food allergies involve the immune system and dietary restrictions, their underlying mechanisms and potential consequences are different. Celiac disease requires lifelong adherence to a gluten-free diet to prevent intestinal damage and long-term health complications. Food allergies require strict avoidance of the specific allergen to prevent allergic reactions.

In conclusion, celiac disease is an autoimmune disorder, not an allergy, and the confusion arises because both involve dietary restrictions related to immune responses.