"Blue cells" can refer to several different things depending on the context. Here are some possibilities:
- Small-blue-round-cell tumors (SBRCTs): These are a group of malignant neoplasms that appear under a microscope as small, round cells that stain blue. SBRCTs can be very aggressive and are often difficult to treat. Some examples of SBRCTs include neuroblastoma, rhabdomyosarcoma, and Ewing's sarcoma.
- Blue cells in cell viability assays: In certain cell viability assays, like the CellTiter-Blue® Cell Viability Assay, living cells convert a redox dye (resazurin) into a fluorescent end product (resorufin). Nonviable cells lose the ability to reduce this dye, leaving them unstained and appearing "blue" under a microscope.
- Blue cells in Trypan Blue exclusion assays: Trypan Blue is a dye that is used to determine cell viability. Dead cells have a compromised cell membrane and allow the dye to enter, making them appear blue.
- Blue cells in the context of skin discoloration: This term can refer to bluish-red skin discoloration that may occur due to a lack of oxygen in the blood. This condition can be caused by various factors, including heart problems, lung disease, and anemia.
