MP cells, in the context of the mononuclear phagocyte system (MPS), are a family of cells encompassing bone marrow progenitors, blood monocytes, and tissue macrophages. Macrophages are a significant cell population in most bodily tissues, and their numbers increase during inflammation, injury, and cancer.
Here's a breakdown:
- Mononuclear Phagocyte System (MPS): A crucial part of the immune system.
- MP Cells Composition:
- Bone Marrow Progenitors: Precursor cells originating in the bone marrow that differentiate into monocytes and macrophages.
- Blood Monocytes: Circulating immune cells in the bloodstream. They migrate into tissues and develop into macrophages.
- Tissue Macrophages: Resident immune cells in tissues throughout the body, playing a vital role in tissue homeostasis and defense.
Macrophages are key players in:
- Immune Defense: Engulfing and destroying pathogens.
- Tissue Repair: Removing dead cells and debris.
- Inflammation: Initiating and resolving inflammatory responses.
The number of macrophages increases significantly in:
- Inflammation: To fight infection and promote healing.
- Wounding: To clear debris and facilitate tissue repair.
- Malignancy: Macrophages can have both tumor-promoting and tumor-suppressing roles in cancer.
