Xen cells are a valuable model for studying primitive endoderm (PrE) cells. They share similar gene expression, differentiation potential, and lineage restriction with PrE cells, making them useful for research.
In essence, Xen cells provide a simplified system for researchers to:
- Study PrE development: Because Xen cells closely mimic PrE cells, they offer insights into how PrE cells form and function in early development.
- Investigate gene regulation: By comparing gene expression in Xen cells and PrE cells, scientists can identify key genes involved in PrE development.
- Explore differentiation pathways: Researchers can use Xen cells to examine how PrE cells differentiate into various cell types.
- Model lineage restriction: Xen cells exhibit similar lineage restrictions to PrE cells, allowing scientists to study how cell fate is determined.
