Ramos cells are engineered human lymphoma cells widely used as a model for studying B lymphocytes and apoptosis.
Understanding Ramos Cells
Ramos cells are valuable in biological research for several reasons:
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B Lymphocyte Model: They serve as a model to study the function and behavior of B lymphocytes.
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Apoptosis Studies: They are routinely used in experiments investigating programmed cell death (apoptosis).
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PRR Expression: Ramos cells naturally express several Pattern Recognition Receptors (PRRs) like TLR3, TLR7, TLR9, and NOD1. This makes them useful for studying immune responses.
- TLR3, TLR7, TLR9: These Toll-like receptors are involved in recognizing foreign pathogens.
- NOD1: This nucleotide-binding oligomerization domain-containing protein recognizes bacterial peptidoglycans.
Applications of Ramos Cells
Because of their characteristics, Ramos cells are employed in a range of research applications:
- Investigating B cell signaling pathways.
- Analyzing the mechanisms of apoptosis.
- Studying the role of PRRs in immune response.
- Testing new therapeutic agents that target B cells or modulate apoptosis.
