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Do Cells Have Voltage?

Published in Cell Membrane Potential 2 mins read

Yes, cells do have voltage, but not in the way you might initially think. The statement "cells have voltage" is imprecise. It's more accurate to say that there is a voltage difference or electrical potential difference across a cell's membrane. This is due to an uneven distribution of ions (like sodium, potassium, and chloride) inside and outside the cell. This difference is crucial for many cellular processes.

Understanding Cellular Voltage

  • Membrane Potential: Cells maintain an electrical potential across their membranes, typically ranging from -40mV to -90mV (millivolts). This is called the resting membrane potential. The negative sign indicates that the inside of the cell is more negatively charged relative to the outside.
  • Ion Gradients: This potential difference is established and maintained by ion pumps and channels in the cell membrane. These pumps actively transport ions against their concentration gradients, creating an imbalance of charge.
  • Variability: The exact voltage across a cell's membrane varies considerably depending on the cell type, its environment, and its activity. A generalized value like 0.07V is an oversimplification and shouldn't be taken as a universal constant. The statement that a human cell generates 0.07 volts of electricity is inaccurate without specifying the location of the measurement (across the membrane, and which cell).
  • Voltage-Gated Channels: Many cellular processes, such as nerve impulses and muscle contractions, rely on voltage-gated ion channels. These channels open or close in response to changes in the membrane potential, allowing ions to flow and further altering the voltage. Voltage-dependent ion channels in glial cells show that even the microenvironment of a cell influences its voltage. Voltage-Gated Ion Channels in Human Pancreatic β-Cells are an example of how this voltage difference is functionally important.
  • Voltage Gradients: Voltage isn't uniform within a cell. Yes, you can also have voltage gradients within cells and outside cells, though these quickly equalize except across membranes.

The idea of harnessing the combined voltage of all cells in a human body is flawed. These voltages are not additive in a straightforward manner. The voltages are across membranes and are not connected in series to create a large voltage.