Yes, RAC ultimately leads to the inhibition of Rho.
Here's how, based on the provided reference (Nimnual et al., 2003):
- Rac stimulates the production of oxygen radicals.
- These oxygen radicals then inhibit a protein called low molecular weight protein tyrosine phosphatase (LMW-PTP).
- Inhibition of LMW-PTP causes increased phosphorylation and activation of p190RhoGAP.
- p190RhoGAP, once activated, inactivates Rho.
Therefore, the pathway initiated by Rac ultimately results in Rho inactivation.
| Step | Explanation |
|---|---|
| Rac Activation | Triggers the process. |
| Oxygen Radical Production | Rac leads to the generation of oxygen radicals. |
| LMW-PTP Inhibition | Oxygen radicals inhibit LMW-PTP. |
| p190RhoGAP Activation | Inhibition of LMW-PTP activates p190RhoGAP. |
| Rho Inactivation | Activated p190RhoGAP inactivates Rho, thus inhibiting it. |
