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What is the difference between cytokines and interleukins?

Published in Cell Signaling 2 mins read

The core difference lies in their scope: cytokines are a broad category of signaling proteins, while interleukins are a specific type of cytokine.

Understanding Cytokines

Cytokines are a diverse group of small proteins released by cells that have a crucial role in cell signaling. They are involved in a wide variety of biological processes, including:

  • Immune responses: Cytokines help regulate inflammation and fight off infections.
  • Cell growth and differentiation: They play a role in how cells develop and specialize.
  • Tissue repair: Cytokines contribute to the healing and regeneration of damaged tissues.

Cytokines can be produced by various cells, including immune cells (like lymphocytes), as well as non-immune cells (like endothelial cells).

Interleukins: A Subgroup of Cytokines

Interleukins (ILs) are a subset of cytokines that are primarily known for their role in communication between white blood cells. The term "interleukin" actually means "between leukocytes" (leukocytes being white blood cells).

  • Interleukins are vital for coordinating immune responses.
  • They can activate, suppress, or modulate immune cells.
  • For example, as the reference states, Interleukin-2 (IL-2) helps immune system cells grow and divide more quickly. This is crucial for mounting a strong defense against pathogens.

Key Differences in Summary

Here's a breakdown of the differences between cytokines and interleukins:

Feature Cytokines Interleukins
Definition Broad category of signaling proteins Specific group of cytokines
Primary Function Cell signaling, diverse biological processes Primarily cell communication between white blood cells
Specificity Can be produced by many cell types and have diverse functions Primarily produced by white blood cells and modulate immune responses
Scope Wide range of roles in the body Narrowly focused on immune regulation
Example Include interferons, chemokines, and interleukins IL-2, IL-6, IL-10, among many others

Conclusion

Interleukins are a specific type of cytokine, emphasizing their role in immune cell communication. While all interleukins are cytokines, not all cytokines are interleukins.