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Which Cells Digest Cholesterol?

Published in Cellular Metabolism 2 mins read

The provided reference does not directly state which cells digest cholesterol. It explains that while most cells can synthesize cholesterol, hepatocytes (liver cells) are primarily responsible for synthesizing and taking up cholesterol. The reference also notes that cholesterol is transported in the blood to peripheral cells.

Here's a breakdown of cholesterol handling:

  • Hepatocytes (Liver Cells):
    • Synthesize most of the body's cholesterol.
    • Take up cholesterol from the blood.
    • Package cholesterol into lipoproteins for transport.
  • Peripheral Cells:
    • Receive cholesterol from the blood.
    • Maintain a balance of cholesterol uptake and export.

The question asks about digestion, which implies breaking down cholesterol, not just uptake, synthesis or transport. Since the provided reference does not explicitly say which cells digest cholesterol, this question may be misleading and needs reframing. However, understanding that cholesterol is modified and transported by specific cells before being utilized may be relevant:


Cell Type Primary Function Role in Cholesterol Handling
Hepatocytes Liver cells Synthesize, take up, and package cholesterol for transport.
Peripheral Cells Cells throughout the body Receive and use cholesterol from the blood; maintain cholesterol levels.


In summary, while many cells use cholesterol and hepatocytes process it in some ways, the reference does not specify which cells are involved in the digestion (breakdown) of cholesterol. This likely involves complex metabolic processes that are not explicitly captured in the information provided.