Lipolysis itself is not usually painful, but you might experience sensations like heat or cooling depending on the specific procedure used.
While some lipolysis techniques, such as laser lipolysis, are done with local anesthesia, others, like noninvasive laser lipolysis, don't require anesthesia as there are no incisions. After the procedure, you might experience minimal swelling, bruising, and pain. However, these side effects are typically short-lived.
It's important to note that lipolysis using unapproved fat-dissolving injections can be harmful and cause pain, redness, and even painful knots.