No, calamine is not an antibiotic.
Calamine lotion is primarily used as an anti-itch and skin protectant. It works by providing a cooling sensation as it evaporates, which helps to relieve itching and discomfort. It also helps to dry out oozing or weeping from minor skin irritations, such as those caused by poison ivy, insect bites, or chickenpox. The active ingredients are typically zinc oxide and ferric oxide.
While calamine can help soothe irritated skin and create a protective barrier, it does not kill bacteria or prevent infection like an antibiotic would. Antibiotics target and destroy bacteria, preventing them from multiplying. Calamine's function is solely to relieve discomfort and protect the skin, it does not address bacterial infections.