DNA relay, in the context described, is a mechanism for directed transport of chromosomal regions. Specifically, the ParB-rich cargo utilizes the elastic force of DNA. This is achieved by ParB associating with one or more ParA dimers until ATP hydrolysis occurs (31). A mathematical model suggests that this DNA-relay mechanism can explain the directed transport of chromosomal regions.
In simpler terms, imagine a package (the ParB-rich cargo) needing to be moved along a rope (DNA). The package grabs onto the rope using special connectors (ParA dimers). These connectors hold tight until they use up their energy (ATP hydrolysis), then they release the rope, and the package moves along. This process repeats, allowing the package to be transported along the DNA.
Key aspects of the DNA relay mechanism include:
- ParB-rich cargo: The "package" being transported.
- ParA dimers: The "connectors" that bind to DNA.
- Elastic force of DNA: The "rope" providing the pathway.
- ATP hydrolysis: The "energy" source that drives the movement.
The DNA-relay mechanism is particularly relevant to understanding how chromosomal regions are transported in organisms like Caulobacter crescentus.
