Several drugs interact significantly with isosorbide mononitrate, primarily those used to treat erectile dysfunction and pulmonary hypertension. These interactions are considered severe due to the potential for dangerously low blood pressure.
Severe Interactions with Isosorbide Mononitrate
Isosorbide mononitrate, a medication often prescribed for angina (chest pain), works by relaxing and widening blood vessels. When combined with certain other medications, this effect can be amplified, leading to a sudden and significant drop in blood pressure, which can be life-threatening.
The following drugs are known to have severe interactions with isosorbide mononitrate:
| Drug Category | Specific Drugs |
|---|---|
| Phosphodiesterase-5 (PDE5) Inhibitors (commonly used for erectile dysfunction or pulmonary hypertension) | Avanafil, Sildenafil, Tadalafil, Vardenafil |
| Soluble Guanylate Cyclase (sGC) Stimulators (used for pulmonary hypertension) | Riociguat |
It is crucial for individuals taking isosorbide mononitrate to be aware of these interactions.
Important Considerations
- Consult Your Doctor: Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs, supplements, and herbal remedies, before starting any new prescription. This ensures your doctor can assess potential drug interactions and adjust your treatment plan as needed.
- Emergency Situations: If you are taking isosorbide mononitrate and experience symptoms of very low blood pressure (such as dizziness, lightheadedness, fainting, or blurred vision), seek immediate medical attention.
- Patient Safety: Never take any of the interacting drugs listed above if you are currently on isosorbide mononitrate, unless specifically instructed and closely monitored by a healthcare professional.
For more detailed information on isosorbide mononitrate, including its uses, side effects, and interactions, you can consult reputable sources such as RxList.
