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How does ruxolitinib work?

Published in Drug Mechanisms 1 min read

Ruxolitinib functions as a kinase inhibitor to treat certain conditions.

Ruxolitinib is used to treat myelofibrosis, polycythemia vera (PV), and graft-versus-host disease (GVHD). It works by blocking specific signals within cells, thereby affecting cell behavior. Here’s a breakdown:

  • Myelofibrosis and PV: Ruxolitinib blocks signals that cause cancer cells to multiply. This action helps to halt the spread of these cells.

  • GVHD: It inhibits the signals of cells responsible for causing GVHD.

In summary, Ruxolitinib's mechanism involves inhibiting kinase signals, which are crucial for cell proliferation and immune responses in myelofibrosis, PV, and GVHD. By blocking these signals, the drug helps manage these conditions.