Yes, endothelin is a local peptide hormone.
Endothelin is a potent substance produced by vascular endothelial cells that has significant effects on the body. Here's a breakdown:
- What it is: According to research, endothelin is a local peptide hormone.
- Where it's produced: It's synthesized by vascular endothelial cells, which are the cells lining the inside of blood vessels.
- Its primary function: Endothelin is identified as the most potent vasoconstrictor known. Vasoconstriction is the narrowing of blood vessels, which increases blood pressure.
- Other Roles: There's increasing evidence that endothelin plays a role in regulating vascular tone and blood pressure, and in the pathophysiology of cardiovascular, renal and respiratory disease.
In summary, endothelin fits the definition of a hormone because it's a signaling molecule produced by cells in the body that has effects on other cells, especially those in the cardiovascular system.
