The exact causes of Contact Lens Papillary Conjunctivitis (CLPC) are not fully understood, but there are two main hypotheses regarding its development.
While the underlying mechanisms remain unclear, research suggests different triggers for localized and generalized CLPC, as summarized below:
Hypothesized Causes of CLPC
| Type of CLPC | Proposed Cause | Reference |
|---|---|---|
| Localized | Mechanical trauma to the conjunctiva, potentially from ill-fitting or damaged contact lenses. | 4, 8 |
| Generalized | An immunological response to bio-deposits (proteins, lipids, etc.) that accumulate on the surface of contact lenses. | 4, 8 |
In simpler terms:
- Local CLPC: This is believed to stem from physical irritation. Think of it like a small scratch or rubbing that causes inflammation in a specific area of the eye.
- General CLPC: This is thought to be an allergic reaction to the buildup of substances on the lenses. The body's immune system reacts to these deposits, leading to widespread inflammation.
While it's unclear what specifically sets off CLPC in each case, it's good to:
- Ensure properly fitted contact lenses.
- Maintain a rigorous cleaning schedule for contact lenses to remove buildup.
- Consider using daily disposable lenses to minimize bio-deposit accumulation.
