Giant papillary conjunctivitis (GPC) is primarily caused by irritation to the inner eyelid, often stemming from contact lenses or other foreign materials.
Here's a more detailed breakdown:
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Mechanical Irritation: This is a primary driver of GPC.
- A contact lens, artificial eye, or even exposed stitches can rub against the conjunctiva (the inner lining of the eyelid).
- This constant friction leads to inflammation and the formation of papillae (small bumps) on the inner eyelid.
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Deposits on Contact Lenses:
- Proteins, lipids, and other substances can build up on the surface of contact lenses.
- These deposits irritate the conjunctiva, triggering an inflammatory response.
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Allergic Reactions:
- Allergies to the materials used in contact lenses themselves can cause GPC.
- Allergies to the chemicals found in contact lens cleaning solutions are another potential trigger.
In summary, GPC arises from a combination of physical irritation and allergic/inflammatory responses to foreign bodies in contact with the inner eyelid. Proper contact lens hygiene and appropriate lens selection can help prevent GPC.
