DLX6 primarily functions by promoting cell proliferation and survival.
Based on the provided reference, the key function identified for DLX6 is its role in supporting cell growth and preventing cell death. This action is particularly noted in the context of certain diseases.
DLX6 Function in Detail
The function of DLX6 varies depending on the biological context and cell type. However, the reference highlights a specific role:
- Promoting Cell Proliferation and Survival: In oral squamous cell carcinoma, DLX6 is shown to actively support the growth (proliferation) and persistence (survival) of cancer cells. This suggests that DLX6 contributes to the progression of this type of cancer.
The reference also mentions the long non-coding RNA DLX6-AS1, which influences cellular processes like proliferation, invasion, and apoptosis (programmed cell death) in endometrial cancer by interacting with the promoter region of the DLX6 gene. While this shows how DLX6 expression or activity can be regulated and linked to cell behavior in another cancer type, the direct function of DLX6 itself, as stated in the reference regarding a specific context, is the promotion of cell proliferation and survival in oral squamous cell carcinoma.
Key Information from the Reference
Here's a breakdown of the core information about DLX6 from the provided source:
| Function | Context | Associated Molecule/Mechanism (in different context) |
|---|---|---|
| Promotes cell proliferation | Oral squamous cell carcinoma | DLX6-AS1 influencing DLX6 promoter in Endometrial Cancer |
| Promotes cell survival | Oral squamous cell carcinoma | DLX6-AS1 influencing DLX6 promoter in Endometrial Cancer |
| (In Endometrial Cancer) Indirectly involved via promoter in affecting proliferation, invasion, and apoptosis | Endometrial cancer | DLX6-AS1 recruiting p300/E2F1 to DLX6 promoter |
- Note: The direct function of DLX6 as stated in the reference is specifically linked to oral squamous cell carcinoma. The information about DLX6-AS1 relates to how DLX6 gene activity might be regulated in a different cancer type (endometrial cancer).
Understanding the function of genes like DLX6 is crucial in cancer research, as it can help identify potential targets for new therapies aimed at inhibiting cancer cell growth and survival.
