Maturity-Onset Diabetes of the Young (MODY) is not caused by a single gene, but rather by mutations in any of several different genes.
Several genes are known to cause different subtypes of MODY. Here are some examples:
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HNF1A: Mutations in the HNF1A gene cause HNF1A-MODY, the most common form of MODY.
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GCK: Mutations in the GCK gene cause GCK-MODY, which is characterized by mild, stable hyperglycemia.
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HNF4A: Mutations in the HNF4A gene cause HNF4A-MODY.
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HNF1B: Mutations in the HNF1B gene cause HNF1B-MODY (also known as RCAD when associated with renal cysts and diabetes).
In summary, different genes can cause MODY, and the specific gene involved determines the subtype and characteristics of the diabetes. Genetic testing is important to identify the specific gene mutation responsible for MODY in an individual.
