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What are the Symptoms of Large Red Blood Cells?

Published in Hematology 2 mins read

The symptoms associated with large red blood cells (macrocytes) are generally related to the underlying condition causing the increased cell size, rather than the large cells themselves. These symptoms often resemble those of anemia.

Macrocytic Anemia and Related Symptoms

When large red blood cells lead to macrocytic anemia (a condition where you have fewer red blood cells than normal, and those cells are larger than normal), you may experience the following:

  • General Anemia Symptoms:
    • Weakness
    • Fatigue
    • Pale skin
    • Shortness of breath
    • Dizziness
    • Headaches

Symptoms Related to the Underlying Cause

Often, macrocytic anemia is caused by a nutritional deficiency, particularly a deficiency in Vitamin B12 or Folate. In these cases, you might also experience:

  • Vitamin B12 Deficiency:
    • Neurological problems (numbness, tingling in hands and feet)
    • Problems with balance
    • Memory problems
    • Depression
    • Sore tongue
  • Folate Deficiency:
    • Diarrhea
    • Irritability
    • Poor growth (in children)

Other Potential Causes and Symptoms

While vitamin deficiencies are common causes, other conditions can also lead to large red blood cells. The symptoms will vary based on the specific condition. Some examples include:

  • Liver disease: Symptoms vary depending on the specific liver condition.
  • Hypothyroidism: Fatigue, weight gain, constipation, dry skin.
  • Myelodysplastic syndromes: Fatigue, frequent infections, easy bleeding or bruising.

In summary, if you have large red blood cells, you might not experience specific symptoms directly attributable to the cell size. Instead, you are more likely to experience symptoms tied to anemia or the root cause of the macrocytosis, such as vitamin deficiency. It's essential to consult a healthcare professional for accurate diagnosis and treatment.