No, hCG does not stop testosterone production; rather, it stimulates testosterone production in the testes.
Here's a detailed explanation:
hCG (human Chorionic Gonadotropin) mimics the action of LH (Luteinizing Hormone). LH signals the testes to produce testosterone. Therefore, when hCG is administered, it binds to the same receptors as LH in the testes, triggering the Leydig cells to synthesize and secrete testosterone.
How hCG Works:
- Mimics LH: hCG is structurally similar to LH.
- Binds to LH Receptors: It binds to the LH receptors on Leydig cells in the testes.
- Stimulates Testosterone Production: This binding stimulates the production of testosterone.
Clinical Uses of hCG:
- Hypogonadism Treatment: hCG is used to treat hypogonadism (low testosterone) in men.
- Fertility Treatment: It's also used in fertility treatments to stimulate testosterone production and sperm production.
- Maintaining Intratesticular Testosterone during TRT: Low doses of HCG can be used alongside Testosterone Replacement Therapy (TRT) to help maintain testosterone production within the testes, even while the body's natural gonadotropin production may be suppressed due to the exogenous testosterone. This is especially important for preserving fertility.
In summary, hCG acts like LH, prompting the testicles to produce more testosterone, rather than suppressing it.
