A BT cell can refer to several things, depending on the context. The ambiguity arises because "BT" isn't a standard, universally recognized abbreviation in biology or medicine. Therefore, we'll explore the most likely interpretations based on the provided references:
1. B Cell and T Cell in the context of the Immune System
This is the most probable meaning considering the provided references. B cells and T cells are both types of lymphocytes, crucial components of the adaptive immune system.
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B Cells: These white blood cells produce antibodies. When they detect harmful germs (antigens), they create antibodies to neutralize them. https://my.clevelandclinic.org/health/body/24669-b-cells B cells are involved in the acquired or antigen-specific immune response. https://www.ncbi.nlm.nih.gov/books/NBK459471/ They are active participants in autoimmune diseases. https://www.nature.com/articles/s41573-020-00092-2 Axicabtagene ciloleucel (axi-cel) is an example of a CAR T-cell therapy that targets B cells in refractory large B-cell lymphoma. https://www.nejm.org/doi/full/10.1056/NEJMoa1707447
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T Cells: These lymphocytes also play a vital role in the adaptive immune response. They don't produce antibodies but instead directly attack infected cells or help regulate the immune response. They are mentioned in the provided text alongside B cells as key players in the acquired immune system. https://www.ncbi.nlm.nih.gov/books/NBK459471/
A "BT cell" in this context is simply a shorthand (though unconventional) reference to both B and T cells together. A blood test might screen for both B and T lymphocyte levels. https://medlineplus.gov/ency/article/003329.htm
2. BT Cell Line (CRL-1390)
This refers to a specific cell line, BT, obtained from a cow's turbinate (part of the nasal passages). https://www.atcc.org/products/crl-1390 This cell line is commercially available and used in research. The abbreviation here is likely specific to this particular cell line and isn't a general biological term.
In summary, the meaning of "BT cell" depends entirely on the context. Without further clarification, the most likely interpretation is a reference to B and T lymphocytes in the immune system.
