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What is the difference between immunoglobulin and immune globulin?

Published in Immunology Terminology 2 mins read

There is no difference between immunoglobulin and immune globulin; they are two different names for the same substance.

Both terms refer to a substance made from human blood plasma. This plasma, which is processed from donated human blood, contains antibodies. These antibodies are crucial for protecting the body against diseases.

Understanding Immunoglobulin/Immune Globulin

Here's a breakdown:

  • What it is: Immunoglobulin (Ig), also known as immune globulin, is a collection of antibodies extracted from human blood plasma.
  • Source: It comes from the plasma of donated human blood.
  • Function: These antibodies within the immunoglobulin protect the body from infections and diseases.
  • Alternative Names: The terms "immunoglobulin," "gamma globulin," and "immune globulin" are all used interchangeably.

Key Aspects of Immunoglobulin/Immune Globulin:

  • Antibodies: The main active component of immunoglobulin/immune globulin is antibodies, also called immunoglobulins. These proteins are produced by the immune system to recognize and fight off harmful substances like viruses and bacteria.
  • Passive Immunity: When you receive immunoglobulin, you are essentially getting pre-made antibodies, which is known as passive immunity. This is different from active immunity, which your body develops on its own after being exposed to a disease or after vaccination.
  • Medical Uses: Immunoglobulin is often administered to individuals with compromised immune systems, or to those who need immediate protection against specific diseases. Examples include:
    • Treating immunodeficiency disorders
    • Managing certain autoimmune diseases
    • Providing post-exposure prophylaxis against infectious diseases like hepatitis or measles.

Table Comparing Immunoglobulin and Immune Globulin

Feature Immunoglobulin (Ig) Immune Globulin
Alternative Names Gamma globulin, Immune Globulin Immunoglobulin, Gamma Globulin
Definition Substance from blood plasma with antibodies Substance from blood plasma with antibodies
Origin Donated human blood plasma Donated human blood plasma
Function Provides passive immunity; fights diseases Provides passive immunity; fights diseases
Difference None, same substance None, same substance

In conclusion, the terms immunoglobulin and immune globulin are interchangeable and refer to the same antibody-rich product derived from human plasma.