While the precise chromosomal location of the KRIT1 gene itself is not detailed in the provided information, studies have specifically identified the cellular localization of the KRIT1 protein, which is encoded by the KRIT1 gene. The protein's presence within the cell reveals key insights into its function.
Cellular Localization of the KRIT1 Protein
During the interphase stage of the cell cycle, the KRIT1 protein is primarily found within the cytoplasm of cells. Observations from immunocytochemistry studies have indicated that KRIT1 exhibits a distinct pattern of localization within the cytoplasm, strongly suggesting its association with the cellular skeletal framework.
Specifically, research has shown that KRIT1 is associated with microtubules, which are vital components of the cytoskeleton. This association highlights KRIT1's role in maintaining cellular structure and potentially in processes involving microtubule dynamics.
Key Aspects of KRIT1 Protein Localization:
- Primary Location: Cytoplasm
- Cellular Phase: Observed during interphase
- Associated Structures: Cytoskeleton, specifically microtubules
This cellular positioning is critical for the protein's various functions, including its involvement in conditions like cerebral cavernous malformation when the KRIT1 gene is mutated. Understanding the protein's localization helps in deciphering its cellular roles and mechanisms of action.
For further details on KRIT1 and its cellular associations, you can refer to relevant scientific literature such as the article discussing KRIT1's association with microtubules on PMC NCBI.
