Lipoatrophy is a condition characterized by the loss of fat tissue, particularly subcutaneous adipose tissue. It can occur due to various reasons, including genetic, immune, infectious, or drug-related factors.
- Genetic Factors: Some forms of lipoatrophy, like Dunnigan-type familial partial lipodystrophy, are caused by mutations in specific genes.
- Immune System-Related Diseases: Conditions like HIV infection, lupus erythematosus, and localized scleroderma can trigger lipoatrophy.
- Infections: Certain infections, though not fully understood, can contribute to lipoatrophy.
- Drug Use: Some medications, particularly antiretroviral drugs used for HIV treatment, have been linked to lipoatrophy.
Lipoatrophy can occur in various locations, including the face, limbs, and abdominal regions, affecting body shape and overall health.
