What Happens When DHEA is High in Men?

When Dehydroepiandrosterone (DHEA) levels are high in men, it indicates that the body is producing an excessive amount of this hormone. This elevation is often a crucial signal of underlying health issues, particularly those affecting the adrenal glands.

Potential Causes of High DHEA

An elevated DHEA level, specifically DHEA-sulfate (DHEA-S), is commonly associated with adrenal gland abnormalities. The primary reasons for an overproduction of DHEA-S include:

• Adrenal Cancer: Malignant growths within the adrenal glands can lead to uncontrolled hormone production.
• Adrenal Tumors: Both benign and malignant tumors of the adrenal glands can cause an excess of hormones, including DHEA.
• Adrenal Hyperplasia: This refers to an excess growth of the adrenal hormone-producing tissue, leading to an overactive gland.

What High DHEA Levels May Mean for Men

While DHEA itself is a precursor, high levels can lead to an increased conversion into more potent androgens (male hormones) like testosterone. This can manifest in various ways:

• Hormonal Imbalance Symptoms:
  • Skin Issues: Increased incidence of acne.
  • Hair Changes: Possible hair loss or thinning on the scalp (androgenic alopecia), and conversely, increased body hair growth.
  • Aggression or Irritability: While less common, significant hormonal shifts can influence mood.
• Underlying Health Concerns: The presence of high DHEA-S levels primarily signifies the need for further medical investigation to rule out or diagnose the aforementioned adrenal conditions. These conditions themselves can have serious health implications beyond just hormonal symptoms.

Importance of Diagnosis and Management

High DHEA-S is not merely a symptom but a critical indicator. If an individual's DHEA-S levels are found to be high, it necessitates a thorough medical evaluation to determine the exact cause. This evaluation typically involves:

1. Further Blood Tests: To assess other hormone levels and related markers.
2. Imaging Studies: Such as CT scans or MRIs of the adrenal glands, to identify tumors or hyperplasia.
3. Specialized Endocrine Testing: To pinpoint the specific nature of the adrenal dysfunction.

Accurate diagnosis is paramount, as the treatment for high DHEA-S will depend entirely on the underlying cause. Addressing the root issue, whether it's a tumor, cancer, or hyperplasia, is essential for managing the hormonal imbalance and preserving overall health.

For more information on DHEA levels and their significance, consult reliable medical resources like MedlinePlus.