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In Which Stage of the Menstrual Cycle Is Progesterone Highest?

Published in Menstrual Cycle Hormones 1 min read

Progesterone levels are highest during the luteal and secretory phases of the menstrual cycle.

The Role of Progesterone

During the menstrual cycle, hormones fluctuate, triggering different events. Progesterone is a key player, especially after ovulation.

The Luteal and Secretory Phases

  • Dominant Hormone: As referenced, the luteal and secretory phase is dominated by progesterone. This phase occurs after ovulation, when the follicle that released the egg transforms into the corpus luteum.
  • Stimulation by LH: Luteinizing hormone (LH) stimulates the corpus luteum to produce progesterone.
  • Endometrial Maturation: Progesterone's primary role is to prepare the uterine lining (endometrium) for potential implantation of a fertilized egg. The endometrium thickens and becomes more vascular under the influence of progesterone. This is essential for the early stages of pregnancy.


Phase Dominant Hormone Key Function
Luteal and Secretory Progesterone Prepares endometrium for potential implantation


Practical Insight

  • If fertilization does not occur, the corpus luteum degenerates, and progesterone levels decline, triggering menstruation.
  • Measuring progesterone levels can be an indicator of ovulation and can be important in fertility assessments.