IMG cells are a type of cell that expresses microglia-specific markers and exhibits characteristic microglial functions. Here's a more detailed look:
Characteristics of IMG Cells
- Microglia Markers: IMG cells display markers typically found on microglia, indicating their identity is closely related to these immune cells of the central nervous system.
- Response to Inflammation: They respond to both pro-inflammatory (promoting inflammation) and anti-inflammatory (reducing inflammation) stimuli.
- Phagocytosis: IMG cells are capable of phagocytosis, meaning they can engulf and digest foreign particles and cellular debris.
- Amyloid-beta Interaction: Notably, IMG cells are robustly activated by amyloid-beta 1-42 (Aβ1–42), a key component of amyloid plaques found in Alzheimer's disease, and can also phagocytose it.
Summary Table
| Feature | Description |
|---|---|
| Markers | Express microglia-specific markers |
| Inflammation Response | Responds to both pro- and anti-inflammatory stimuli |
| Phagocytosis | Capable of phagocytosing foreign particles |
| Aβ1–42 Interaction | Robustly activated by Aβ1–42 and phagocytose Aβ1–42 |
