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Is there translation in mitochondria?

Published in Mitochondrial Translation 1 min read

Yes, there is translation in mitochondria.

Mitochondria possess their own protein synthesis machinery, which includes ribosomes called mitoribosomes, that perform translation. According to the provided reference, translation in mitochondria is indeed carried out by specialized mitoribosomes. Let's explore some key aspects of this process:

Mitoribosomes: The Protein Factories of Mitochondria

Mitoribosomes are structurally distinct from cytoplasmic ribosomes and are specifically adapted for mitochondrial translation.

  • Composition: Mammalian mitoribosomes are composed of two subunits: a large subunit (39S) and a small subunit (28S).
  • rRNA and Proteins: The large subunit contains a 16S rRNA and 48 proteins, while the small subunit contains a 12S rRNA and 30 proteins.
Mitoribosome Subunit Components
Large Subunit (39S) 16S rRNA, 48 proteins
Small Subunit (28S) 12S rRNA, 30 proteins

This specialized machinery allows mitochondria to synthesize a subset of proteins essential for their function, particularly those involved in the electron transport chain and oxidative phosphorylation.