In biology, NBS stands for nucleotide-binding site. It is a domain found in certain proteins, particularly plant disease resistance proteins.
Nucleotide-Binding Site (NBS) Explained
The nucleotide-binding site (NBS) is a protein domain responsible for binding nucleotides such as ATP or GTP. It is a crucial component of several proteins involved in various cellular processes.
NBS in Plant Disease Resistance
- Role: In the context of plant disease resistance, NBS domains are often found within a class of proteins known as NBS-LRR proteins.
- NBS-LRR Proteins: These proteins play a vital role in plant immunity by recognizing pathogen-derived molecules and triggering defense responses. The reference states that "Most plant disease resistance (R) proteins contain a series of leucine-rich repeats (LRRs), a nucleotide-binding site (NBS), and a putative amino-terminal signaling domain. They are termed NBS-LRR proteins."
- Structure: NBS-LRR proteins typically contain:
- Leucine-rich repeats (LRRs): Involved in pathogen recognition.
- Nucleotide-binding site (NBS): Regulates protein activity.
- Amino-terminal signaling domain: Triggers downstream signaling pathways.
Function of NBS domain
The NBS domain regulates protein activity. This regulation is crucial for the proper functioning of these resistance proteins.
