There is no established scientific term or concept called "covalent mass." The provided references refer to the use of mass spectrometry in studying covalent bonds and molecules, but not to a specific quantity or property called "covalent mass." Instead, the references highlight the use of mass spectrometry to analyze molecules with covalent bonds, which helps determine molecular mass (or formula mass for covalent compounds).
Understanding Molecular Mass in Covalent Compounds
For covalent substances, the formula represents the number and types of atoms in a single molecule. Therefore, the formula mass is often called the molecular mass. This molecular mass is determined by summing the atomic masses of all atoms present in the molecule. The references demonstrate the application of this principle using mass spectrometry techniques to study various molecules.
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Mass Spectrometry and Covalent Interactions: Several provided articles detail the use of mass spectrometry (MS) to analyze covalent interactions in proteins and other molecules. These studies leverage MS to identify and quantify covalent bonds, such as those formed between proteins and inhibitors (e.g., High-Throughput Mass Spectrometric Analysis of Covalent Protein...), or to analyze the higher-order structure of proteins (Covalent Labeling-Mass Spectrometry with Non-Specific Reagents ...).
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Covalent Modifiers and Mass Spectrometry: Researchers use covalent labeling techniques combined with MS to analyze various aspects of molecules. For instance, covalent labeling helps analyze monoclonal antibodies' higher-order structures (Covalent Labeling/Mass Spectrometry of Monoclonal Antibodies ...), and identify protein-inhibitor adducts (High-Throughput Mass Spectrometric Analysis of Covalent Protein...).
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Applications in Drug Discovery: Covalent bonding is exploited in drug development. The use of covalent inhibitors and the study of their interactions are relevant to drug discovery and development, as shown in various references.
Therefore, while "covalent mass" isn't a defined term, understanding molecular mass within the context of covalent molecules and its analysis via mass spectrometry techniques is crucial in various scientific fields.
