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# What is the Drug of Choice for ODD?

Published in ODD Medication 2 mins read

For Oppositional Defiant Disorder (ODD), there is no specific medication that is FDA-approved as a "drug of choice" for its treatment in the U.S.

Despite the absence of FDA-approved drugs specifically for ODD, clinical experience suggests that some children and adolescents with ODD may show signs of improvement in their symptoms when prescribed certain medications. These are typically used at low doses.

Medications Used Based on Clinical Experience

While not FDA-approved for ODD, atypical neuroleptics are sometimes utilized due to observed positive outcomes in clinical settings. These medications can help manage some challenging behaviors associated with ODD.

Common examples of atypical neuroleptics that have shown signs of improvement in clinical experience include:

  • Aripiprazole (Abilify)
  • Risperidone (Risperdal)

It's important to note that the decision to use medication is often made on a case-by-case basis, considering the individual's specific symptoms, co-occurring conditions (like ADHD or anxiety), and overall treatment plan. Medication is typically part of a broader, comprehensive approach to managing ODD.

Overview of Medications for ODD (Based on Clinical Practice)

Medication (Generic Name) Common Brand Name Class of Medication Notes on Use for ODD
Aripiprazole Abilify Atypical Neuroleptic Clinical experience indicates potential for improvement in ODD symptoms when used at low doses, especially for irritability or aggression.
Risperidone Risperdal Atypical Neuroleptic Similar to aripiprazole, risperidone has shown signs of improvement in ODD symptoms in children and adolescents based on clinical observation, particularly for disruptive behaviors.