No, it is generally not recommended to take Xtampza ER and additional oxycodone simultaneously, as both medications contain the same active ingredient, oxycodone.
Understanding Xtampza ER and Oxycodone
Xtampza ER is an extended-release formulation of oxycodone, designed to provide consistent pain relief over an extended period. This means that Xtampza ER already contains oxycodone, slowly releasing it into your system. Taking additional oxycodone, such as an immediate-release tablet, at the same time as Xtampza ER would effectively double or significantly increase your oxycodone intake.
Why This Combination is Dangerous
Combining Xtampza ER with additional oxycodone can lead to dangerously high levels of oxycodone in your body, resulting in severe and potentially fatal adverse effects.
- Increased Oxycodone Plasma Concentrations: When you take more oxycodone than prescribed, the concentration of the drug in your bloodstream (plasma concentration) rises significantly. Medical warnings indicate that an increase in oxycodone plasma concentrations can substantially increase or prolong adverse drug effects.
- Potentially Fatal Respiratory Depression: One of the most critical risks associated with excessive oxycodone levels is respiratory depression. This condition can slow down or even stop your breathing, which can be fatal.
- Profound Sedation and Coma: High doses of oxycodone can cause extreme drowsiness, confusion, and loss of consciousness, potentially leading to a coma.
- Other Severe Side Effects: Overdosing on oxycodone can also cause pinpoint pupils, cold and clammy skin, circulatory collapse, and even death.
Risks Associated with Taking Xtampza ER and Additional Oxycodone
| Risk Factor | Description | Potential Consequence |
|---|---|---|
| Drug Overdose | Taking two forms of oxycodone concurrently results in an overall higher dosage than prescribed, leading to excessive drug levels in the body. | Severe side effects, life-threatening complications, death. |
| Central Nervous System Depression | Elevated oxycodone levels suppress brain activity, affecting vital functions like breathing and consciousness. | Respiratory arrest, coma, irreversible brain damage. |
| Increased Adverse Effects | The risk and severity of common opioid side effects such as nausea, vomiting, constipation, and dizziness are significantly heightened. | Impaired daily functioning, severe discomfort. |
| Addiction and Dependence | Misuse of opioid medications, including taking higher doses than prescribed, greatly increases the risk of developing physical dependence and addiction. | Long-term health issues, withdrawal symptoms upon cessation. |
Important Considerations and Medical Advice
- Always Consult a Healthcare Professional: Never adjust your opioid medication dosage or combine different opioid medications without explicit instructions from your doctor. Your healthcare provider is the only one who can safely determine the appropriate dosage and pain management plan for you.
- Managing Breakthrough Pain: If you are prescribed Xtampza ER and experience breakthrough pain, discuss this with your doctor. They may prescribe an immediate-release opioid to be taken only as needed for breakthrough pain, with careful instructions on how to use it safely alongside your Xtampza ER.
- Drug Interactions: Inform your doctor and pharmacist about all medications you are currently taking, including over-the-counter drugs, supplements, and herbal products, to prevent dangerous drug interactions.
Combining opioid medications without strict medical guidance is extremely dangerous and can have severe, life-threatening consequences. Always prioritize your safety and consult with a healthcare professional for all medication-related concerns.
