Apomorphine injection is a medication used to treat "off" episodes in people with advanced Parkinson's disease. These "off" episodes are periods of difficulty with movement, walking, and speaking that can occur as medication wears off or randomly. Apomorphine belongs to a class of drugs called dopamine agonists, meaning it works by mimicking the effects of dopamine in the brain. It's administered via subcutaneous injection (under the skin), typically as an intermittent bolus injection, and must not be given intravenously.
Understanding Apomorphine Injection
- Mechanism of Action: Apomorphine acts as a dopamine receptor agonist, effectively replacing the dopamine that is deficient in Parkinson's disease. This helps to alleviate the motor symptoms experienced during "off" episodes.
- Administration: Apomorphine is administered as a subcutaneous injection using devices like the APO-go Pen. It's crucial to note that intravenous administration is contraindicated.
- Use in Parkinson's Disease: It specifically targets the debilitating "off" periods experienced by individuals with advanced Parkinson's, significantly improving their quality of life.
- Example: A patient experiencing stiffness and difficulty walking during an "off" episode might receive an apomorphine injection to quickly relieve these symptoms.
Different Types of Apomorphine Injections
While the primary use is focused on Apomorphine for treating Parkinson's disease "off" episodes, the references also mention other types of injections that incorporate "APO" in their names, which should not be confused with Apomorphine injections:
- APO-go Pen: This is a specific brand name for a pre-filled pen injector delivering apomorphine for subcutaneous use.
- APO-KETAMINE: This is a ketamine-based injection, a completely different medication with distinct uses. This highlights the importance of clarifying which "APO" injection is being discussed.
- Apolipoprotein (apo) studies: Research involving apolipoproteins, such as apo A-I, use injections in animal models. These are distinct from the therapeutic use of apomorphine.
This information is based on several sources, including MedlinePlus, Parkinson's UK, and various pharmaceutical product summaries. Always consult with a healthcare professional for accurate information and guidance regarding specific medical treatments.
