Methergine (methylergonovine) is given in postpartum hemorrhage (PPH) primarily to prevent and control excessive bleeding from the uterus after childbirth.
How Methergine Works in PPH:
Methergine belongs to a class of medications known as ergot alkaloids. It works by:
- Stimulating Uterine Contractions: Methergine acts directly on the smooth muscles of the uterus, causing them to contract strongly and rhythmically.
- Reducing Bleeding: These strong contractions help to compress the blood vessels in the uterus, effectively reducing bleeding. After childbirth, the uterus needs to contract down to its pre-pregnancy size. Methergine helps facilitate this process, preventing the uterus from becoming "boggy" (atonic) and unable to control bleeding.
- Preventing Postpartum Hemorrhage: By promoting uterine contractions, Methergine helps to prevent and manage PPH, a serious complication of childbirth.
Key Uses of Methergine in PPH:
- Treatment of Postpartum Hemorrhage: It's used to stop bleeding that has already started after delivery.
- Prevention of Postpartum Hemorrhage: In some cases, it can be given proactively to prevent excessive bleeding, particularly in women at higher risk.
Important Considerations:
While Methergine is effective, its use isn't always appropriate. Contraindications include:
- Hypertension: Methergine can increase blood pressure, making it unsuitable for women with pre-existing or pregnancy-induced hypertension (preeclampsia/eclampsia).
- Sensitivity to Ergot Alkaloids: Allergic reactions are possible.
It's crucial to follow a healthcare provider's instructions carefully when using Methergine.
