Yes, PPIs may reduce testosterone levels in some patients.
While the effect is not universal, here's a breakdown based on the provided reference:
- Mechanism: Proton pump inhibitors (PPIs) can induce the CYP3A4 enzyme.
- Impact: This induction may lead to lower testosterone levels in some individuals.
In other words, PPIs might indirectly influence testosterone production in certain people by affecting enzyme systems involved in hormone metabolism.
