Salinomycin exhibits distinct solubility characteristics, being highly soluble in various organic solvents and insoluble in water, which is crucial for its handling and application.
Solubility in Organic Solvents
Salinomycin is readily soluble in a range of organic solvents, making it versatile for different research and formulation purposes. One primary solvent for salinomycin is dimethyl sulfoxide (DMSO). It can be supplied as a concentrated solution, for instance, a 0.2 µm-filtered, 2 mg/mL solution in DMSO, which is equivalent to 2.66 mM.
Beyond DMSO, salinomycin demonstrates good solubility in several other organic compounds, including:
- Alcohols
- Esters
- Chloroform
- Ether
- Carbon tetrachloride
- Hexane
These properties highlight its lipophilic nature, making it suitable for dissolution in non-polar to moderately polar organic media.
Insolubility in Water
Conversely, salinomycin is insoluble in water. This characteristic is significant for its application, as it means salinomycin cannot be directly dissolved in aqueous solutions without the aid of specific solubilizing agents or formulation techniques.
Summary of Salinomycin Solubility
To provide a clear overview, the solubility of salinomycin in common solvents is summarized below:
| Solvent Type | Specific Solvents | Solubility | Key Information |
|---|---|---|---|
| Highly Soluble | Dimethyl Sulfoxide (DMSO) | Excellent | Typically supplied as 2 mg/mL (2.66 mM) solution |
| Soluble | Alcohols, Esters, Chloroform, Ether, Carbon Tetrachloride, Hexane | Good | Dissolves readily in these organic compounds |
| Insoluble | Water | Negligible to None | Cannot be dissolved directly in water |
These solubility properties are vital for researchers and pharmacists when preparing salinomycin solutions for various applications, including in vitro studies and specialized formulation development where an organic solvent carrier is often required.
