While research is somewhat limited, current evidence suggests omeprazole likely does not significantly affect sperm quality.
Here's a breakdown of what the available evidence indicates:
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In Vitro Studies: Studies examining omeprazole's effects directly on sperm in a laboratory setting ("in vitro") have found that omeprazole, even at varying concentrations, did not negatively impact sperm motility (movement), viability (living sperm count), or DNA integrity [16].
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Patient-Based Studies: A large retrospective study involving infertile men found no significant correlation between proton pump inhibitor (PPI) use (which includes omeprazole) and semen quality [14].
Therefore, the available research suggests that omeprazole does not negatively affect sperm quality. However, more research is always beneficial to further confirm these findings, especially large-scale, prospective studies. Individual reactions to medications can vary, so consulting with a healthcare professional is always recommended if concerns arise.
