While the exact cause of fibroid growth isn't definitively known, research indicates a strong link to hormones, particularly estrogen and progesterone.
According to available information, no one knows for sure what causes fibroids, we also don't know what causes them to grow or shrink. However, we do know that they are under hormonal control — both estrogen and progesterone. They tend to grow rapidly during pregnancy, a time when hormone levels are high. Conversely, they shrink when anti-hormone medication is used.
This suggests that fluctuations in estrogen and progesterone levels play a significant role in stimulating fibroid growth.
Factors Influencing Fibroid Growth (Based on Hormonal Connection)
Based on the known hormonal influence, several factors or periods in a person's life might impact fibroid growth:
- Pregnancy: High levels of estrogen and progesterone during pregnancy are associated with rapid fibroid growth.
- Hormone Therapy: Treatments involving estrogen and progesterone may potentially influence fibroid size.
- Menopause: Fibroids often shrink after menopause when hormone levels decline naturally.
- Anti-Hormone Medications: Medications designed to block or reduce hormone levels are known to cause fibroids to shrink.
While the underlying cellular mechanisms that initiate fibroid formation and growth remain an area of ongoing study, the strong correlation with hormonal activity, as highlighted by their behavior during pregnancy and response to anti-hormone therapy, is a key piece of understanding.