Yes, vitamin D supplementation can reduce CRP (C-reactive protein) concentrations, particularly in studies lasting longer than 3 months and with dosages of ≤1,000 IU/day.
Here's a more detailed explanation:
Studies have shown that vitamin D supplementation is associated with a significant reduction in CRP levels, which is a marker of inflammation in the body. The extent of this reduction appears to be influenced by the duration of supplementation and the dosage used.
- Duration of Supplementation: Research indicates that the reduction in CRP is more pronounced in studies that lasted longer than 3 months. Specifically, one study found a significant reduction in CRP concentrations (MD = –0.91 mg/L; 95% CI –1.37 to –0.45 mg/L; P < .001) after vitamin D supplementation for more than 3 months.
- Dosage: The dosage of vitamin D also plays a role. Studies involving doses of ≤1,000 IU/day showed a significant reduction in CRP (MD = –2.10 mg/L; 95% CI –2.51 to –1.68 mg/L; P < .001).
Therefore, the evidence suggests that vitamin D supplementation can be an effective strategy for reducing inflammation, as indicated by lower CRP levels, especially with longer duration and lower dosages.
